Idebenone CAS 58186-27-9
Idebenone is an organic compound with the chemical name: 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone. It is a structural analogue of coenzyme Q10 and is developed by Takeda Pharmaceuticals as a drug for the treatment of cognitive diseases such as Alzheimer??s disease.
Idebenone has an activating effect on mitochondrial function, improves brain metabolism and brain dysfunction, and can increase the utilization rate of glucose in the brain and promote the generation of ATP; it improves the metabolism of the neurotransmitter 5-hydroxytryptamine in the brain and has a strong antioxidant and free radical scavenging effect. In clinical practice, it is mainly used to treat many central nervous system degenerative diseases related to oxidative stress, such as Parkinson??s disease, Alzheimer??s disease, multi-infarct dementia, local cerebral anemia and brain failure, etc. It is also used to treat Friedreich??s ataxia. It can also be used in cosmetic formulas, with cosmetic efficacy such as scavenging free radicals, inhibiting lipid peroxidation, inhibiting inflammation, inhibiting DNA damage, light protection, and reducing pigmentation.
Idebenone CAS 58186-27-9
| Idebenone Basic information |
| Product Name: | Idebenone |
| Synonyms: | cv 2619 idebenone;Daruma??Mnesis;2,5-Cyclohexadiene-1,4-dione, 5,6-dimethoxy-2-(10-hydroxydecyl)-3-methyl-;6-(10-Hydroxydecyl)ubiquinone;2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione;2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone;IDEBENONE(P);2-(10-Hydroxydecyl)-5??6-dimethoxy-3-methyl-2??5-cyclohexadienPl??4-dione |
| CAS: | 58186-27-9 |
| MF: | C19H30O5 |
| MW: | 338.44 |
| EINECS: | 1308068-626-2 |
| Product Categories: | Aromatics;API;Other APIs;AP;Anthraquinones, Hydroquinones and Quinones;Cnbio;Intermediates & Fine Chemicals;Pharmaceuticals;58186-27-9 |
| Mol File: | 58186-27-9.mol |
 |
|
| Idebenone Chemical Properties |
| Melting point | 52-550C |
| Boiling point | 497.3??45.0 ??C(Predicted) |
| density | 1.08??0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | Solid |
| pka | 15.20??0.10(Predicted) |
| color | Orange |
| Merck | 14,4888 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20??C for up to 3 months. |
| InChI | InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3 |
| InChIKey | JGPMMRGNQUBGND-UHFFFAOYSA-N |
| SMILES | C1(=O)C(OC)=C(OC)C(=O)C(C)=C1CCCCCCCCCCO |
| LogP | 3.490 (est) |
| CAS DataBase Reference | 58186-27-9(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| WGK Germany | 3 |
| RTECS | GU5290000 |
| HS Code | 2933399990 |
Related Products
1-Octanol, also known as Capryl alcohol or n-Octanol, is a clear, colorless liquid with a characteristic waxy odor. It is an alcohol with eight carbon atoms in its chain, making it a part of the aliphatic alcohol family. This compound is poorly soluble in water but is miscible with ethanol, diethyl ether, and chloroform . It has a melting point of approximately -15??C and a boiling point of around 196??C . 1-Octanol is used in the production of esters, plasticizers, and as a solvent or intermediate in the synthesis of various organic compounds. It also finds application in the fragrance industry as a fixative in perfumes and can be used in the formulation of flavor and scent compositions . It is important to note that 1-Octanol is flammable and should be handled with care, storing it away from sources of ignition and heat .
Butylated Hydroxytoluene (BHT) is a synthetic phenolic antioxidant commonly added to foods, cosmetics, and packaging to prevent the oxidation of fats and oils, thereby extending their shelf life. It is also used as a preservative in a variety of products, including rubber, petroleum products, and animal feed. BHT is recognized for its effectiveness in maintaining nutrient levels, color, flavor, and odor in food products . It is known to have a melting point of 69-71??C, a boiling point of 265??C, and is soluble in ethanol, acetone, and benzene, but not in water, glycerin, or propylene glycol . BHT is also used in some dietary supplements due to its antioxidant properties . However, it is important to handle BHT with care, as it can cause skin irritation and is considered harmful if swallowed .
Chemical Name: Zinc citrate
Synonyms: Zinc citrate trihydrate
CAS No.: 546-46-3
Molecular Formula: C6H8O7Zn
Molecular Weight: 257.5
Appearance: White powder
Benzothiazoles are a class of chemical compounds characterized by a fused benzene and thiazole ring. They exhibit a broad spectrum of applications, particularly as antioxidants in rubber and plastic industries, enhancing product longevity and performance. Additionally, benzothiazoles serve as key intermediates in the synthesis of pharmaceuticals, contributing to the development of life-saving drugs. Recognized for their stability and reactivity, these compounds are integral to advancing material science and healthcare solutions.
Chemical Name: Imazalil Sulfate
CAS No.: 58594-72-2
Molecular Formula: C14H14Cl2N2O.H2SO4
Molecular Weight: 395.26
Appearance: Solid
Chemical Name: UV-120
Other Name: (2’,4’-Di-tert-butylphenyl 3,5-di-tert-butyl-4-hydroxybenzoate)
CAS No.: 4221-80-1
Molecular Fomula: C29H42O3
Molecular weight: 438.66
Assay: ≥99%（LC）
Chemical Name: Dehydrocholic acid
Synonyms: Acide dehydrocholique; Triketocholanic acid
CAS No.: 81-23-2
Molecular Formula: C24H34O5
Molecular Weight: 402.53
Appearance: Powder
Product name:Cyclopentane
Purity:96%
Appearance:White powder
Package:25kg/bag
Sample:Available
Silicone oil, known for its chemical designation as dimethicone or polydimethylsiloxane, is a synthetic polymer with a backbone of alternating silicon and oxygen atoms, creating a highly versatile and stable compound. It is renowned for its exceptional lubricating properties, heat resistance, and non-toxic nature, making it a staple in various industries, including cosmetics, automotive, and aerospace.
This hydrophobic, non-volatile oil is valued for its ability to provide a smooth, non-greasy feel and to form stable emulsions with other ingredients. In personal care products, silicone oil is used to impart a silky texture, reduce friction on the skin, and create a protective barrier against environmental stressors without clogging pores.
Silicone oil’s chemical inertness and resistance to oxidation contribute to its long shelf life and stability in formulations. It is also appreciated for its compatibility with a wide range of substances, allowing for the creation of multifunctional products.
In summary, silicone oil is a reliable and multifaceted ingredient, offering a combination of performance, safety, and sensory benefits. Its use in a variety of applications reflects its versatility and enduring appeal in the marketplace.
Silicones are a family of synthetic polymers known for their versatility and stability. They are heat-resistant, non-toxic, and have excellent electrical insulation properties. Commonly used in various industries such as construction, automotive, aerospace, and personal care products, silicones offer a wide range of applications from sealants and adhesives to lubricants and medical devices. Their resistance to extreme temperatures and weathering makes them a preferred choice for many high-performance applications.
Polyhexamethylene guanidine hydrochloride, often abbreviated as PHMG-HCl, is a high molecular weight polymeric biguanide compound known for its potent antimicrobial properties. With a chemical structure that features a long chain of methylene groups bridged by guanidine units, PHMG-HCl is effective against a broad spectrum of microorganisms, including bacteria, viruses, and fungi.
This hydrochloride salt form of PHMG is highly soluble in water and is commonly used in various applications due to its non-irritant and non-toxic nature to human skin and mucous membranes. It is widely recognized for its ability to form a colorless and odorless solution, making it an ideal choice for use in personal care products, medical disinfectants, and water treatment processes.
The versatility of PHMG-HCl lies in its cationic nature, which allows it to bind to negatively charged microbial cell walls, disrupting their integrity and leading to cell death. This mechanism of action contributes to its effectiveness as a preservative and disinfectant. Moreover, its substantivity, or the ability to adhere to surfaces, enhances its long-lasting antimicrobial activity.
In summary, Polyhexamethylene guanidine hydrochloride is a reliable and efficient antimicrobial agent, pivotal in industries where hygiene and cleanliness are paramount, offering a safe and sustainable solution for microbial control.
Octocrylene is an organic compound widely recognized for its potent UV-filtering properties, making it an essential ingredient in sunscreens and other skincare products designed to protect the skin from harmful ultraviolet radiation. With the chemical name 2-(4-Methylbenzyl)-2H-benzotriazole-5-methyl, octocrylene is a stable and photostable molecule that provides broad-spectrum protection against both UVA and UVB rays.
This oil-soluble chemical is valued for its ability to absorb UV radiation effectively, converting it into heat without causing skin irritation or staining clothes. Octocrylene is often used in combination with other UV filters to enhance the sun protection factor (SPF) of formulations, ensuring a balanced and comprehensive defense against sun damage.
As a lipophilic compound, octocrylene is compatible with various cosmetic and dermatological formulations, contributing to the development of lightweight, non-greasy sunscreens. Its chemical structure allows for a high degree of safety and efficacy, making it suitable for a wide range of skin types, including sensitive skin.
In summary, octocrylene is a reliable and efficient UV filter, pivotal in the formulation of modern sunscreens that offer advanced protection against the sun’s harmful effects while maintaining skin comfort and product aesthetics.
