Idebenone CAS 58186-27-9
Idebenone is an organic compound with the chemical name: 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone. It is a structural analogue of coenzyme Q10 and is developed by Takeda Pharmaceuticals as a drug for the treatment of cognitive diseases such as Alzheimer??s disease.
Idebenone has an activating effect on mitochondrial function, improves brain metabolism and brain dysfunction, and can increase the utilization rate of glucose in the brain and promote the generation of ATP; it improves the metabolism of the neurotransmitter 5-hydroxytryptamine in the brain and has a strong antioxidant and free radical scavenging effect. In clinical practice, it is mainly used to treat many central nervous system degenerative diseases related to oxidative stress, such as Parkinson??s disease, Alzheimer??s disease, multi-infarct dementia, local cerebral anemia and brain failure, etc. It is also used to treat Friedreich??s ataxia. It can also be used in cosmetic formulas, with cosmetic efficacy such as scavenging free radicals, inhibiting lipid peroxidation, inhibiting inflammation, inhibiting DNA damage, light protection, and reducing pigmentation.
Idebenone CAS 58186-27-9
| Idebenone Basic information |
| Product Name: | Idebenone |
| Synonyms: | cv 2619 idebenone;Daruma??Mnesis;2,5-Cyclohexadiene-1,4-dione, 5,6-dimethoxy-2-(10-hydroxydecyl)-3-methyl-;6-(10-Hydroxydecyl)ubiquinone;2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione;2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone;IDEBENONE(P);2-(10-Hydroxydecyl)-5??6-dimethoxy-3-methyl-2??5-cyclohexadienPl??4-dione |
| CAS: | 58186-27-9 |
| MF: | C19H30O5 |
| MW: | 338.44 |
| EINECS: | 1308068-626-2 |
| Product Categories: | Aromatics;API;Other APIs;AP;Anthraquinones, Hydroquinones and Quinones;Cnbio;Intermediates & Fine Chemicals;Pharmaceuticals;58186-27-9 |
| Mol File: | 58186-27-9.mol |
 |
|
| Idebenone Chemical Properties |
| Melting point | 52-550C |
| Boiling point | 497.3??45.0 ??C(Predicted) |
| density | 1.08??0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | Solid |
| pka | 15.20??0.10(Predicted) |
| color | Orange |
| Merck | 14,4888 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20??C for up to 3 months. |
| InChI | InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3 |
| InChIKey | JGPMMRGNQUBGND-UHFFFAOYSA-N |
| SMILES | C1(=O)C(OC)=C(OC)C(=O)C(C)=C1CCCCCCCCCCO |
| LogP | 3.490 (est) |
| CAS DataBase Reference | 58186-27-9(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| WGK Germany | 3 |
| RTECS | GU5290000 |
| HS Code | 2933399990 |
Related Products
Chemical Name: Ashwagandha Extract
Synonyms: Withania somnifera, ext.; Withania Somnefera Extract
CAS: 90147-43-6
Appearance: Brown
Chemical Name: o-Xylene
Synonyms: 1,2-Dimethylbenzene; ortho-xylene
CAS No.: 95-47-6
Molecular Formula: C8H10
Molecular Weight: 106.17
1-Octanol, also known as Capryl alcohol or n-Octanol, is a clear, colorless liquid with a characteristic waxy odor. It is an alcohol with eight carbon atoms in its chain, making it a part of the aliphatic alcohol family. This compound is poorly soluble in water but is miscible with ethanol, diethyl ether, and chloroform . It has a melting point of approximately -15??C and a boiling point of around 196??C . 1-Octanol is used in the production of esters, plasticizers, and as a solvent or intermediate in the synthesis of various organic compounds. It also finds application in the fragrance industry as a fixative in perfumes and can be used in the formulation of flavor and scent compositions . It is important to note that 1-Octanol is flammable and should be handled with care, storing it away from sources of ignition and heat .
Ethylhexyl Palmitate is a skin-conditioning ester, derived from ethylhexanol and palmitic acid, that imparts moisturization and a smooth texture to cosmetic and personal care formulations. It is valued for its emollient properties, enhancing the sensory experience of skin care products.
Chemical Name: UV-120
Other Name: (2’,4’-Di-tert-butylphenyl 3,5-di-tert-butyl-4-hydroxybenzoate)
CAS No.: 4221-80-1
Molecular Fomula: C29H42O3
Molecular weight: 438.66
Assay: ≥99%（LC）
Product name:HYDROXYPROPYL GUAR HYDROXYPROPYLTRIMONIUM CHLORIDE
Purity:99%
Appearance:Light Yellow Powder
Package:Customized according to customer needs.
Sample:Available
Polyhexamethylene guanidine hydrochloride, often abbreviated as PHMG-HCl, is a high molecular weight polymeric biguanide compound known for its potent antimicrobial properties. With a chemical structure that features a long chain of methylene groups bridged by guanidine units, PHMG-HCl is effective against a broad spectrum of microorganisms, including bacteria, viruses, and fungi.
This hydrochloride salt form of PHMG is highly soluble in water and is commonly used in various applications due to its non-irritant and non-toxic nature to human skin and mucous membranes. It is widely recognized for its ability to form a colorless and odorless solution, making it an ideal choice for use in personal care products, medical disinfectants, and water treatment processes.
The versatility of PHMG-HCl lies in its cationic nature, which allows it to bind to negatively charged microbial cell walls, disrupting their integrity and leading to cell death. This mechanism of action contributes to its effectiveness as a preservative and disinfectant. Moreover, its substantivity, or the ability to adhere to surfaces, enhances its long-lasting antimicrobial activity.
In summary, Polyhexamethylene guanidine hydrochloride is a reliable and efficient antimicrobial agent, pivotal in industries where hygiene and cleanliness are paramount, offering a safe and sustainable solution for microbial control.
Chemical Name: Arabic gum
CAS No.: 9000-01-5
Appearance: powder
Chemical Name: Choline salicylate
CAS No.: 2016-36-6
Molecular Formula: C12H19NO4
Molecular Weight: 241.28
Appearance: Red-Brown Crystal
Terpene resin is a type of natural resin derived from terpenes, which are organic compounds found in various plants. It is known for its aromatic properties and is commonly used in the production of fragrances, flavorings, and as a component in adhesives and coatings within the chemical industry. Terpene resin offers a range of benefits, including enhancing the solubility of essential oils and providing a stable base for various applications. Its natural origin makes it a preferred choice for eco-friendly products.
POLY(VINYL CHLORIDE-CO-ISOBUTYL VINYL ETHER) is a copolymer that combines the properties of vinyl chloride and isobutyl vinyl ether. This polymer offers a balance of rigidity and flexibility, along with enhanced chemical resistance and durability. It is commonly used in the production of films, coatings, and adhesives due to its excellent barrier properties against gases and moisture, making it ideal for packaging and construction applications.
Silicone oil, known for its chemical designation as dimethicone or polydimethylsiloxane, is a synthetic polymer with a backbone of alternating silicon and oxygen atoms, creating a highly versatile and stable compound. It is renowned for its exceptional lubricating properties, heat resistance, and non-toxic nature, making it a staple in various industries, including cosmetics, automotive, and aerospace.
This hydrophobic, non-volatile oil is valued for its ability to provide a smooth, non-greasy feel and to form stable emulsions with other ingredients. In personal care products, silicone oil is used to impart a silky texture, reduce friction on the skin, and create a protective barrier against environmental stressors without clogging pores.
Silicone oil’s chemical inertness and resistance to oxidation contribute to its long shelf life and stability in formulations. It is also appreciated for its compatibility with a wide range of substances, allowing for the creation of multifunctional products.
In summary, silicone oil is a reliable and multifaceted ingredient, offering a combination of performance, safety, and sensory benefits. Its use in a variety of applications reflects its versatility and enduring appeal in the marketplace.
