Polyhexamethylene Biguanide Hydrochloride CAS #32289-58-0
Polyhexanide (Polyhexamethylene biguanide hydrochloride, PHMB) is a polymer used as a disinfectant and antiseptic. Spelled Polihexanide (inn) for dermatological purposes and sold under the names lavasept, serasept, prontosan and omniside.?PHMB has been shown to be resistant to Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Yeast infection albicans, Aspergillus Brazil, Enterococcus as well as Klebsiella pneumoniae.
The average molecular weight of polyhexamethylene biguanide hydrochloride is 1100-1800, the molecular formula is (C8H17N5)n??xHCl, n=12-16. Polyhexamethylene biguanide hydrochloride (PHMB) is a broad-spectrum antibiotic that can kill gram-positive bacteria, gram-negative bacteria, fungi and yeast.
Polyhexamethylene Biguanide Hydrochloride CAS #32289-58-0
| Poly(hexamethylenebiguanide)hydrochloride Basic information |
| Description?Application?Safety |
| Product Name: | Poly(hexamethylenebiguanide)hydrochloride |
| Synonyms: | POLY(HEXAMETHYLENEBIGUANIDE) HCL;Polyhexamethylene biguanidine;Acticide SR 1296;Arlagard E;BG 1;BG-IR;Cosmocil;Lavasept |
| CAS: | 32289-58-0 |
| MF: | C10H23N5 |
| MW: | 213.32312 |
| EINECS: | 1308068-626-2 |
| Product Categories: | Antibacterial agent;CHEMICAL;Biocide;Fungicide series;Intermediates & Fine Chemicals;Pharmaceuticals;Polymers;Industrial/Fine Chemicals;Water treatment;Disinfectants;PHM;intermediate;32289-58-0 |
| Mol File: | 32289-58-0.mol |
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| Poly(hexamethylenebiguanide)hydrochloride Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Water |
| form | Solid |
| color | White to off-white |
| InChI | InChI=1S/C10H23N5/c1-9(11)14-7-5-3-4-6-8-15-10(12)13-2/h3-8H2,1-2H3,(H2,11,14)(H3,12,13,15) |
| InChIKey | SAGIGHPRUJPLKX-UHFFFAOYSA-N |
| SMILES | C(=N)(C)NCCCCCCNC(=N)NC |
| CAS DataBase Reference | 32289-58-0(CAS DataBase Reference) |
| EPA Substance Registry System | Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride (32289-58-0) |
| Safety Information |
| Hazardous Substances Data | 32289-58-0(Hazardous Substances Data) |
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Polyhexamethylene guanidine hydrochloride, often abbreviated as PHMG-HCl, is a high molecular weight polymeric biguanide compound known for its potent antimicrobial properties. With a chemical structure that features a long chain of methylene groups bridged by guanidine units, PHMG-HCl is effective against a broad spectrum of microorganisms, including bacteria, viruses, and fungi.
This hydrochloride salt form of PHMG is highly soluble in water and is commonly used in various applications due to its non-irritant and non-toxic nature to human skin and mucous membranes. It is widely recognized for its ability to form a colorless and odorless solution, making it an ideal choice for use in personal care products, medical disinfectants, and water treatment processes.
The versatility of PHMG-HCl lies in its cationic nature, which allows it to bind to negatively charged microbial cell walls, disrupting their integrity and leading to cell death. This mechanism of action contributes to its effectiveness as a preservative and disinfectant. Moreover, its substantivity, or the ability to adhere to surfaces, enhances its long-lasting antimicrobial activity.
In summary, Polyhexamethylene guanidine hydrochloride is a reliable and efficient antimicrobial agent, pivotal in industries where hygiene and cleanliness are paramount, offering a safe and sustainable solution for microbial control.
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