Orientin CAS 28608-75-5

Huperzine A is a natural plant extract. Compared with similar AD treatment drugs approved by the US FDA, Huperzine A has a unique chemical structure and has extremely high selectivity to inhibit acetylcholinesterase in the brain and enhance cholinergic in the brain. function of neurons. In addition, Huperzine A has obvious effects on improving memory and improving cognitive ability.

Huperzine A has a small relative molecular weight, high lipid solubility, and is easy to pass through the blood-brain barrier. After entering the central nervous system, it is mostly distributed in the frontal lobe, temporal lobe, hippocampus and other parts of the brain. Its pharmacological effects have multiple targets. In addition to inhibiting the activity of acetylcholinesterase, it can also antagonize oxidative stress and apoptosis induced by ??-amyloid peptide (A??), hydrogen peroxide and other neurotoxins, by activating the protein kinase C (PKC) signal transduction pathway. Activation of ??-secretase promotes the decomposition of ??-amyloid precursor protein (APP) in a non-amyloidogenic manner to produce sAPP??, reducing A??-mediated toxicity, while sAPP?? can effectively promote cell proliferation, axonal growth, and protect nerves. cell.

Puerarin, also known as pueraria flavonoids, is a kind of flavonoid glycoside extracted from the roots of Pueraria alba or Pueraria thomsonii and is also one of the main effective ingredients of Pueraria lobata. That Pueraria lobate was used to treat diseases has already been recorded in China??s ancient medical books such as Shen Nong??s Materia Medica, Treatise on Miscellaneous Diseases and Medical Dictionary.
Kanzu root is widely distributed in our country and of rich resources. It has been reported that puerarin could be extracted from Pueraria lobata (Wild.) Ohwi, Radix Pueraria thomsonii, Pueraria omeiensiswanget Tang, Pueraria edulis Pamp and Pueraria phaseoloides, but the content of puerarin differs.
Pueraria has a great value for nutrition and medicine and was considered the south ginseng of China. Puerarin has been widespread concerned over our country for its use of food and medicine in recent years.