Madecassoside CAS 34540-22-2

Osthole belongs to coumarin compounds. It is prismatic-like crystals (diethyl ether) and needle-like crystals (Ethanol) with the melting point being 83~84 ?? and the boiling point being 145~150 ??. It is soluble in alkaline solution, methanol, ethanol, chloroform, acetone, ethyl acetate, and boiling petroleum ether but insoluble in water and petroleum ether.

Osthole has various kinds of effects of antispasmodic, hypotensive, anti-arrhythmic and enhancing immune function and broad-spectrum antimicrobial effect. Osthole can not only have efficacy such as anti-hypertensive, anti-arrhythmic, anti-inflammatory, anti-tumor and anti-osteoporosis effect, but can also act as a new type of biological pesticides with significant efficacy in treating pests and plant pathogens.

Peony is the dried root of the perennial herbaceous plant Paeoniaceae in the Paeoniaceae family. It is bitter, sour and slightly cold. It returns to the liver and spleen meridians. It has the functions of calming the liver and relieving pain, nourishing blood and regulating menstruation, astringing yin and stopping sweating. It is used for headaches, dizziness, rib pain, abdominal pain, cramps and pain in limbs, blood deficiency and chlorosis, irregular menstruation, spontaneous perspiration, and night sweats.

Paeoniflorin is the main functional component of peony. It is an important physiologically active substance with anti-inflammatory effects, immune system effects, liver protection effects, analgesic effects, etc.

Huperzine A is a natural plant extract. Compared with similar AD treatment drugs approved by the US FDA, Huperzine A has a unique chemical structure and has extremely high selectivity to inhibit acetylcholinesterase in the brain and enhance cholinergic in the brain. function of neurons. In addition, Huperzine A has obvious effects on improving memory and improving cognitive ability.

Huperzine A has a small relative molecular weight, high lipid solubility, and is easy to pass through the blood-brain barrier. After entering the central nervous system, it is mostly distributed in the frontal lobe, temporal lobe, hippocampus and other parts of the brain. Its pharmacological effects have multiple targets. In addition to inhibiting the activity of acetylcholinesterase, it can also antagonize oxidative stress and apoptosis induced by ??-amyloid peptide (A??), hydrogen peroxide and other neurotoxins, by activating the protein kinase C (PKC) signal transduction pathway. Activation of ??-secretase promotes the decomposition of ??-amyloid precursor protein (APP) in a non-amyloidogenic manner to produce sAPP??, reducing A??-mediated toxicity, while sAPP?? can effectively promote cell proliferation, axonal growth, and protect nerves. cell.