Huperzine A CAS# 102518-79-6
Huperzine A is a natural plant extract. Compared with similar AD treatment drugs approved by the US FDA, Huperzine A has a unique chemical structure and has extremely high selectivity to inhibit acetylcholinesterase in the brain and enhance cholinergic in the brain. function of neurons. In addition, Huperzine A has obvious effects on improving memory and improving cognitive ability.
Huperzine A has a small relative molecular weight, high lipid solubility, and is easy to pass through the blood-brain barrier. After entering the central nervous system, it is mostly distributed in the frontal lobe, temporal lobe, hippocampus and other parts of the brain. Its pharmacological effects have multiple targets. In addition to inhibiting the activity of acetylcholinesterase, it can also antagonize oxidative stress and apoptosis induced by ??-amyloid peptide (A??), hydrogen peroxide and other neurotoxins, by activating the protein kinase C (PKC) signal transduction pathway. Activation of ??-secretase promotes the decomposition of ??-amyloid precursor protein (APP) in a non-amyloidogenic manner to produce sAPP??, reducing A??-mediated toxicity, while sAPP?? can effectively promote cell proliferation, axonal growth, and protect nerves. cell.
Huperzine A CAS# 102518-79-6
| (-)-Huperzine A Basic information |
| Huperzia serrata extract?Indications?Side effects?Inhibition?Uses |
| Product Name: | (-)-Huperzine A |
| Synonyms: | Huperzine-A1-5%;(5r-(5-alpha,9-beta,11e))-ydro-7-methyl;5,9-methanocycloocta(b)pyridin-2(1h)-one,5-amino-11-ethylidene-5,6,9,10-tetrah;HUPERIZINE;(-)-HUPERZINE A FROM HUPERZIA SERRATA;HuperziaSerrateP.E120786-18-7/;(5R,9R,E)-5-AMino-11-ethylidene-7-Methyl-5,6,9,10-tetrahydro-5,9-Methanocycloocta[b]pyridin-2(1H)-one;(-)-Huperzine A (HupA) |
| CAS: | 102518-79-6 |
| MF: | C15H18N2O |
| MW: | 242.32 |
| EINECS: | 600-320-6 |
| Product Categories: | Inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Nutritional Ingredients;reference substance;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Acetylcholine receptor;API;Alkaloids;102518-79-6 |
| Mol File: | 102518-79-6.mol |
 |
|
| (-)-Huperzine A Chemical Properties |
| Melting point | 211-216oC |
| alpha | D -147?? (c = 0.36 in CH3OH) (Ayer); D24.5 -150.4?? (c = 0.498 in MeOH) (Liu) |
| Boiling point | 505.0??50.0 ??C(Predicted) |
| density | 1.20??0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8??C |
| solubility | insoluble in H2O; ??12.12 mg/mL in DMSO; ??23.13 mg/mL in EtOH |
| pka | 12.25??0.60(Predicted) |
| form | Solid |
| color | White to Almost white |
| optical activity | [??]/D -153??5??, c = 0.5 in methanol |
| InChI | InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1 |
| InChIKey | ZRJBHWIHUMBLCN-YQEJDHNASA-N |
| SMILES | C12C[C@@]3([H])/C(=CC)/[C@@](N)(C=1C=CC(=O)N2)CC(C)=C3 |
| LogP | 0.833 (est) |
| CAS DataBase Reference | 102518-79-6(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28-36/37/38 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 1544 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | PB9185700 |
| HS Code | 29339900 |
Related Products
Common English name: 5-iodo-2,3-dihydropyridazin-3-one
CAS No.: 825633-94-1
Molecular formula: C4H3IN2O
Molecular weight: 221.98
Sample: Available
Chemical Name:?Ptaquiloside
CAS No.: 87625-62-5
Molecular Formula: C20H30O8
Molecular Weight: 398.45
Appearance: White Powder
Hydroxytyrosol, a potent antioxidant polyphenol derived from olives, is celebrated for its health-promoting properties. Highly valued in the nutraceutical, cosmetic, and pharmaceutical sectors, it contributes to the development of products that support well-being and skin health.
Hydroxytyrosol has anti-inflammatory effects, dilates blood vessels and antibacterial effects, can prevent atherosclerosis, can reduce the incidence of certain cancers (such as breast, prostate, endometrial, digestive tract); Due to its strong antioxidant activity and the effect of reducing the incidence of cancer, hydroxytyrosol has great prospects for medical use. Hydroxytyrosol is a tyrosol metabolite that is also found in olive oil and contains strong antioxidant propertie.
Product name:Cyclopentane
Purity:96%
Appearance:White powder
Package:25kg/bag
Sample:Available
Osthole belongs to coumarin compounds. It is prismatic-like crystals (diethyl ether) and needle-like crystals (Ethanol) with the melting point being 83~84 ?? and the boiling point being 145~150 ??. It is soluble in alkaline solution, methanol, ethanol, chloroform, acetone, ethyl acetate, and boiling petroleum ether but insoluble in water and petroleum ether.
Osthole has various kinds of effects of antispasmodic, hypotensive, anti-arrhythmic and enhancing immune function and broad-spectrum antimicrobial effect. Osthole can not only have efficacy such as anti-hypertensive, anti-arrhythmic, anti-inflammatory, anti-tumor and anti-osteoporosis effect, but can also act as a new type of biological pesticides with significant efficacy in treating pests and plant pathogens.
Chemical Name: 3-Hydroxybutyric acid
CAS No.: 625-71-8
Molecular Formula: C4H8O3
Molecular Weight: 104.1
Appearance: White powder
Chemical Name: Dehydrocholic acid
Synonyms: Acide dehydrocholique; Triketocholanic acid
CAS No.: 81-23-2
Molecular Formula: C24H34O5
Molecular Weight: 402.53
Appearance: Powder
Chemical Name: Reishi Mushroom Extract
CAS No.: /
Molecular Fomula: C16H23O15
Chemical Structure: /
Molecular weight: /
Appearance:Brown powder
Arbutin, a derivative of hydroquinone, is a naturally occurring compound extracted primarily from the bearberry plant (Arctostaphylos uva-ursi). It is renowned in the skincare industry for its skin lightening properties, making it a popular ingredient in cosmetic products designed to reduce hyperpigmentation and even out skin tone.
Chemically, arbutin is ??-glucosiduronic acid of hydroquinone, with the molecular formula C12H12O7. Its mechanism of action involves the inhibition of tyrosinase, a key enzyme in the melanin biosynthesis pathway. By reducing melanin production, arbutin effectively lightens the skin without the risk of irritation often associated with hydroquinone.
Arbutin is valued for its safety profile, as it is considered less irritating and more stable compared to other skin lightening agents. It is also known for its antioxidant properties, which contribute to its skin brightening effects and overall skin health benefits.
In summary, arbutin is a reliable and gentle alternative for skin lightening, offering a natural approach to reducing pigmentation issues while promoting a more radiant and even complexion. Its use in skincare formulations is favored for its efficacy and mildness, making it suitable for various skin types.
Chemical Name: UV-120
Other Name: (2’,4’-Di-tert-butylphenyl 3,5-di-tert-butyl-4-hydroxybenzoate)
CAS No.: 4221-80-1
Molecular Fomula: C29H42O3
Molecular weight: 438.66
Assay: ≥99%（LC）
