COENZYME A SODIUM SALT CAS# 55672-92-9

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Coenzyme A sodium salt hydrate (CAS 55672-92-9) is an important biologically active substance.
Appearance: Usually white or off-white powder. Solubility: Easily soluble in water, forming a clear solution in water.
Function: In the body, coenzyme A sodium salt hydrate is an important coenzyme that participates in a variety of biochemical reactions. It plays a key role in the metabolism of fatty acids, promoting the activation and oxidative decomposition of fatty acids. It participates in the tricarboxylic acid cycle and provides energy for cells. It is also important for the metabolism of certain amino acids.
Application: Commonly used in biochemistry and molecular biology research as a cofactor for enzyme reactions.
In the field of medicine, it may be used in the treatment or adjuvant treatment of certain diseases.

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COENZYME A SODIUM SALT CAS# 55672-92-9

COENZYME A SODIUM SALT Basic information

Product Name:	COENZYME A SODIUM SALT
Synonyms:	CoenzymeA hydrate sodium salt;coenzyme A sodium from yeast;COENZYME A, SODIUM CELL CULTURE TESTED;COENZYME A DISODIUM SALT;COENZYME A SODIUM SALT;COENZYME A SODIUM SALT HYDRATE;COENZYME A TRISODIUM SALT;COA NA2
CAS:	55672-92-9
MF:	C21H35N7NaO16P3S
MW:	789.52
EINECS:	259-747-8
Product Categories:
Mol File:	55672-92-9.mol

COENZYME A SODIUM SALT Chemical Properties

storage temp.	?20??C
solubility	H2O: soluble50mg/mL, clear, colorless to faintly yellow

Safety Information

Safety Statements	22-24/25
WGK Germany	3
F	3-10-23

MSDS Information

Provider	Language
SigmaAldrich	English

COENZYME A SODIUM SALT Usage And Synthesis

Uses

Coenzyme A is suitable for use in:

gylcerolipid biosynthesis in porcine adipose tissue
an assay to measure the level of Alpha-methylacyl-CoA racemase (AMACR) in human blood samples using a nanoparticle electrochemical biosensor
chloramphenicol acetyltransferase (CAT) assay
the synthesis of palmitoyl-CoA, which is required for palmitoylation and activation of proteins for regulated membrane fusion

General Description

Coenzyme A (CoA) is an essential cofactor in living systems and is synthesized from pantothenic acid (vitamin B5), The CoA levels in mitochondria and peroxisomes correspond to 2-5 mM and 0.7 mM, respectively. Cytosolic CoA is in the range of 0.05 mM to 0.14 mM

Biochem/physiol Actions

Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes. In the presence of CoASH, organic carboxylic acids form acyl-CoA thioesters, which facilitates enzyme recognition. The acyl-CoA formed from xenobiotic carboxylic acids can add to the compound??s toxicity, which can lead to cellular metabolic dysfunction. It is involved in the oxidation of pyruvate in the Kreb??s cycle. CoA is needed for metabolic events. The bacterial CoA pathway is targeted for antimicrobial development. It mediates acyl group transfer and carbonyl activation. The CoA and its thioester levels are crucial for cellular homeostasis. CoA is also involved in regulating platelet aggregation and vasoconstriction. It acts as an essential cofactor in enzymatic acetyl transfer reactions.