Urapidil Hydrochloride CAS# 34661-75-1
Urapidil is a sympathetic antihypertensive drug. It acts as ?? 1 ?C adrenoceptor antagonists and 5-HT 1A receptor agonists act. Although the initial report showed that urapidil was also a ?? 2 ?C adrenoceptor agonist, which was not confirmed in later studies, proved that it had no agonist effect in the saphenous vein of dogs and ileum of guinea pigs. With others ?? Unlike 1-adrenoceptor villains, urapidil does not cause response tachycardia, which may be connected to its weak ?? 1-adrenoceptor antagonist activity and its impact on heart vagal drive. Urapidil has actually not been approved by the US Food and drug administration, yet it is offered in Europe.
Urapidil (URA), chemical name is 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl -2,4(1H,3H)-pyrimidinedione, trade name: ebrantil (ebrantil), synonym: excellent matchi, uracil substituted by phenazine.
Urapidil Hydrochloride CAS# 34661-75-1
| 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Basic information |
| Product Name: | 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil |
| Synonyms: | 1,3-dimethyl-6-(3-(4-(o-methoxyphenyl)-1-piperazinyl)proppylamino)-uraci;6-(3-(4-(o-methoxyphenyl)-1-piperazinyl)propylamino)-1,3-dimethyluracil;b-66256;6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil;UrapidilC20H29N503;URAPIDIL [6-((3-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)PROPYL)AMINO)-1,3-DIMETHYLURACIL];1,3-Dimethyl-6-[3-[4-(o-methoxyphenyl)piperazin-1-yl]propylamino]uracil;BKU |
| CAS: | 34661-75-1 |
| MF: | C20H29N5O3 |
| MW: | 387.48 |
| EINECS: | 252-130-4 |
| Product Categories: | EBRANTIL;API;API’s;34661-75-1 |
| Mol File: | 34661-75-1.mol |
![6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Structure](https://www.chemicalbook.com/CAS/GIF/34661-75-1.gif) |
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| 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Chemical Properties |
| Melting point | 156-158?? |
| Boiling point | 513.42??C (rough estimate) |
| density | 1.2058 (rough estimate) |
| refractive index | 1.7600 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: 25 mg/mL (64.52 mM); Water: < 0.1 mg/mL (insoluble) |
| form | powder to crystal |
| pka | 7.10(at 25??) |
| color | White to Light yellow to Light orange |
| ??max | 268nm(MeOH)(lit.) |
| Merck | 14,9865 |
| CAS DataBase Reference | 34661-75-1(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| RTECS | YQ9862000 |
| HS Code | 2933.59.8000 |
| Toxicity | LD50 in male mice, rats (mg/kg): 750, 550 orally; 260, 145 i.v. (Koenig) |
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