Pyridine-3-sulfonyl chloride CAS 16133-25-8
Chemical Name: pyridine-3-sulfonyl chloride
Synonyms: m-Pyridinesulfonyl chloride
CAS No.: 16133-25-8
Molecular Fomula: C5H4ClNO2S
Molecular weight: 177.61
Appearance: Colorless to pale yellow liquid
Assay: 99 % min
Pyridine-3-sulfonyl Chloride (CAS 16133-25-8): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Pyridine-3-sulfonyl chloride (CAS 16133-25-8) is a specialized sulfonating agent with the molecular formula C5H4ClNO2S. It is widely used in pharmaceutical and chemical synthesis.
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| Purity | ≥98% | ≥95% | ≥97% |
| Melting Point | 89-92°C | 85-88°C | 90-93°C |
| Storage | 2-8°C, inert atmosphere | Ambient | 4-10°C |
2. Key Applications
- Pharmaceutical Intermediates: Synthesis of sulfonamide-based drugs.
- Agrochemicals: Production of herbicidal compounds.
- Material Science: Modification of polymer surfaces.
3. Usage Guidelines
Typical Reaction Conditions
- Solvent: Dichloromethane or THF
- Temperature: 0-5°C (initial), room temperature for completion
- Molar Ratio: 1:1.2 (substrate:sulfonyl chloride)
4. Case Studies
Case 1: Anticancer Drug Synthesis
Used in a 3-step synthesis of PD-1/PD-L1 inhibitors, achieving 82% yield with >99% purity.
Case 2: Polymer Functionalization
Enhanced hydrophilicity of polyetheretherketone (PEEK) membranes for biomedical applications.
5. Customer Success Stories
| Customer | Application | Result |
|---|---|---|
| PharmaTech Inc. (USA) | HIV protease inhibitor development | Reduced synthesis steps from 5 to 3 |
| EuroChem Research (Germany) | Herbicide formulation | 15% efficacy improvement |
6. Contact for Custom Solutions
Request bulk pricing or technical support:
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