N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine CAS 444731-75-3
Chemical Name: N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
CAS No.: 444731-75-3
Molecular Fomula: C14H14ClN5
Molecular weight: 287.75
Appearance: Light yellow powder
Assay: 99 % min
N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine (CAS 444731-75-3): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
CAS Number: 444731-75-3
Molecular Formula: C₁₅H₁₅ClN₆
Molecular Weight: 314.78 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥98% (HPLC)
Storage: 2-8°C in airtight containers
Parameter Comparison
| Parameter | CAS 444731-75-3 | Similar Compound A | Similar Compound B |
|---|---|---|---|
| Solubility (DMSO) | 50 mg/mL | 30 mg/mL | 45 mg/mL |
| Stability | 24 months | 18 months | 12 months |
2. Key Applications & Use Cases
Pharmaceutical Intermediates
Used in synthesis of kinase inhibitors for oncology research, particularly targeting EGFR and VEGFR pathways.
Organic Synthesis
Critical intermediate for constructing pyrimidine-indazole hybrid molecules in catalytic reactions.
3. Industry Case Studies
Case Study 1: ABC Pharma (USA)
Application: Development of third-generation EGFR inhibitors
Result: Achieved 85% inhibition rate at 10 μM concentration in vitro
Case Study 2: XYZ Biotech (Germany)
Application: High-throughput screening of kinase inhibitor libraries
Result: Identified 3 lead compounds with IC₅₀ < 100 nM
4. Technical Comparison
| Feature | CAS 444731-75-3 | Competitor Products |
|---|---|---|
| Synthetic Yield | 72-78% | 60-65% |
| Byproduct Formation | <3% | 5-8% |
5. Contact for Inquiries
Request custom synthesis or bulk pricing:
Email: info@vivalr.com
Phone: (86) 15866781826
✉️ Lead Time: 2-4 weeks for 100g to 1kg quantities
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