Idebenone CAS 58186-27-9
Idebenone is an organic compound with the chemical name: 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone. It is a structural analogue of coenzyme Q10 and is developed by Takeda Pharmaceuticals as a drug for the treatment of cognitive diseases such as Alzheimer??s disease.
Idebenone has an activating effect on mitochondrial function, improves brain metabolism and brain dysfunction, and can increase the utilization rate of glucose in the brain and promote the generation of ATP; it improves the metabolism of the neurotransmitter 5-hydroxytryptamine in the brain and has a strong antioxidant and free radical scavenging effect. In clinical practice, it is mainly used to treat many central nervous system degenerative diseases related to oxidative stress, such as Parkinson??s disease, Alzheimer??s disease, multi-infarct dementia, local cerebral anemia and brain failure, etc. It is also used to treat Friedreich??s ataxia. It can also be used in cosmetic formulas, with cosmetic efficacy such as scavenging free radicals, inhibiting lipid peroxidation, inhibiting inflammation, inhibiting DNA damage, light protection, and reducing pigmentation.
Idebenone CAS 58186-27-9
| Idebenone Basic information |
| Product Name: | Idebenone |
| Synonyms: | cv 2619 idebenone;Daruma??Mnesis;2,5-Cyclohexadiene-1,4-dione, 5,6-dimethoxy-2-(10-hydroxydecyl)-3-methyl-;6-(10-Hydroxydecyl)ubiquinone;2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione;2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone;IDEBENONE(P);2-(10-Hydroxydecyl)-5??6-dimethoxy-3-methyl-2??5-cyclohexadienPl??4-dione |
| CAS: | 58186-27-9 |
| MF: | C19H30O5 |
| MW: | 338.44 |
| EINECS: | 1308068-626-2 |
| Product Categories: | Aromatics;API;Other APIs;AP;Anthraquinones, Hydroquinones and Quinones;Cnbio;Intermediates & Fine Chemicals;Pharmaceuticals;58186-27-9 |
| Mol File: | 58186-27-9.mol |
 |
|
| Idebenone Chemical Properties |
| Melting point | 52-550C |
| Boiling point | 497.3??45.0 ??C(Predicted) |
| density | 1.08??0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | Solid |
| pka | 15.20??0.10(Predicted) |
| color | Orange |
| Merck | 14,4888 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20??C for up to 3 months. |
| InChI | InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3 |
| InChIKey | JGPMMRGNQUBGND-UHFFFAOYSA-N |
| SMILES | C1(=O)C(OC)=C(OC)C(=O)C(C)=C1CCCCCCCCCCO |
| LogP | 3.490 (est) |
| CAS DataBase Reference | 58186-27-9(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| WGK Germany | 3 |
| RTECS | GU5290000 |
| HS Code | 2933399990 |
Related Products
Silicone oil, known for its chemical designation as dimethicone or polydimethylsiloxane, is a synthetic polymer with a backbone of alternating silicon and oxygen atoms, creating a highly versatile and stable compound. It is renowned for its exceptional lubricating properties, heat resistance, and non-toxic nature, making it a staple in various industries, including cosmetics, automotive, and aerospace.
This hydrophobic, non-volatile oil is valued for its ability to provide a smooth, non-greasy feel and to form stable emulsions with other ingredients. In personal care products, silicone oil is used to impart a silky texture, reduce friction on the skin, and create a protective barrier against environmental stressors without clogging pores.
Silicone oil’s chemical inertness and resistance to oxidation contribute to its long shelf life and stability in formulations. It is also appreciated for its compatibility with a wide range of substances, allowing for the creation of multifunctional products.
In summary, silicone oil is a reliable and multifaceted ingredient, offering a combination of performance, safety, and sensory benefits. Its use in a variety of applications reflects its versatility and enduring appeal in the marketplace.
Chemical Name: Potassium Castorate
CAS No.: 8013-05-6
Molecular Formula: C57H107K3O12
Molecular Weight: 1101.74718
Appearance: Yellow Liquid
Chemical Name: 1,1,2,2-Tetrachloroethane
Other Name: Tetrachlorethane
CAS No.: 79-34-5
Molecular Formula: C2H2Cl4
Molecular Weight: 167.85
Appearance: Liquid
Benzothiazoles are a class of chemical compounds characterized by a fused benzene and thiazole ring. They exhibit a broad spectrum of applications, particularly as antioxidants in rubber and plastic industries, enhancing product longevity and performance. Additionally, benzothiazoles serve as key intermediates in the synthesis of pharmaceuticals, contributing to the development of life-saving drugs. Recognized for their stability and reactivity, these compounds are integral to advancing material science and healthcare solutions.
Terpene resin is a type of natural resin derived from terpenes, which are organic compounds found in various plants. It is known for its aromatic properties and is commonly used in the production of fragrances, flavorings, and as a component in adhesives and coatings within the chemical industry. Terpene resin offers a range of benefits, including enhancing the solubility of essential oils and providing a stable base for various applications. Its natural origin makes it a preferred choice for eco-friendly products.
Chemical Name: Ashwagandha Extract
Synonyms: Withania somnifera, ext.; Withania Somnefera Extract
CAS: 90147-43-6
Appearance: Brown
Chemical Name: UV-120
Other Name: (2’,4’-Di-tert-butylphenyl 3,5-di-tert-butyl-4-hydroxybenzoate)
CAS No.: 4221-80-1
Molecular Fomula: C29H42O3
Molecular weight: 438.66
Assay: ≥99%（LC）
Ethylhexyl Palmitate is a skin-conditioning ester, derived from ethylhexanol and palmitic acid, that imparts moisturization and a smooth texture to cosmetic and personal care formulations. It is valued for its emollient properties, enhancing the sensory experience of skin care products.
Octocrylene is an organic compound widely recognized for its potent UV-filtering properties, making it an essential ingredient in sunscreens and other skincare products designed to protect the skin from harmful ultraviolet radiation. With the chemical name 2-(4-Methylbenzyl)-2H-benzotriazole-5-methyl, octocrylene is a stable and photostable molecule that provides broad-spectrum protection against both UVA and UVB rays.
This oil-soluble chemical is valued for its ability to absorb UV radiation effectively, converting it into heat without causing skin irritation or staining clothes. Octocrylene is often used in combination with other UV filters to enhance the sun protection factor (SPF) of formulations, ensuring a balanced and comprehensive defense against sun damage.
As a lipophilic compound, octocrylene is compatible with various cosmetic and dermatological formulations, contributing to the development of lightweight, non-greasy sunscreens. Its chemical structure allows for a high degree of safety and efficacy, making it suitable for a wide range of skin types, including sensitive skin.
In summary, octocrylene is a reliable and efficient UV filter, pivotal in the formulation of modern sunscreens that offer advanced protection against the sun’s harmful effects while maintaining skin comfort and product aesthetics.
Chemical Name: Arabic gum
CAS No.: 9000-01-5
Appearance: powder
Chemical Name: Dehydrocholic acid
Synonyms: Acide dehydrocholique; Triketocholanic acid
CAS No.: 81-23-2
Molecular Formula: C24H34O5
Molecular Weight: 402.53
Appearance: Powder
Chemical Name: Ammonium Iron(II) Sulfate
Synonyms: Diammonium iron bis(sulphate); iron (ii) ammonium sulfate
CAS No.: 10045-89-3
Molecular Formula: FeH5NO4S
Molecular Weight: 170.95
