Huperzine A CAS# 102518-79-6
Huperzine A is a natural plant extract. Compared with similar AD treatment drugs approved by the US FDA, Huperzine A has a unique chemical structure and has extremely high selectivity to inhibit acetylcholinesterase in the brain and enhance cholinergic in the brain. function of neurons. In addition, Huperzine A has obvious effects on improving memory and improving cognitive ability.
Huperzine A has a small relative molecular weight, high lipid solubility, and is easy to pass through the blood-brain barrier. After entering the central nervous system, it is mostly distributed in the frontal lobe, temporal lobe, hippocampus and other parts of the brain. Its pharmacological effects have multiple targets. In addition to inhibiting the activity of acetylcholinesterase, it can also antagonize oxidative stress and apoptosis induced by ??-amyloid peptide (A??), hydrogen peroxide and other neurotoxins, by activating the protein kinase C (PKC) signal transduction pathway. Activation of ??-secretase promotes the decomposition of ??-amyloid precursor protein (APP) in a non-amyloidogenic manner to produce sAPP??, reducing A??-mediated toxicity, while sAPP?? can effectively promote cell proliferation, axonal growth, and protect nerves. cell.
Huperzine A CAS# 102518-79-6
| (-)-Huperzine A Basic information |
| Huperzia serrata extract?Indications?Side effects?Inhibition?Uses |
| Product Name: | (-)-Huperzine A |
| Synonyms: | Huperzine-A1-5%;(5r-(5-alpha,9-beta,11e))-ydro-7-methyl;5,9-methanocycloocta(b)pyridin-2(1h)-one,5-amino-11-ethylidene-5,6,9,10-tetrah;HUPERIZINE;(-)-HUPERZINE A FROM HUPERZIA SERRATA;HuperziaSerrateP.E120786-18-7/;(5R,9R,E)-5-AMino-11-ethylidene-7-Methyl-5,6,9,10-tetrahydro-5,9-Methanocycloocta[b]pyridin-2(1H)-one;(-)-Huperzine A (HupA) |
| CAS: | 102518-79-6 |
| MF: | C15H18N2O |
| MW: | 242.32 |
| EINECS: | 600-320-6 |
| Product Categories: | Inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Nutritional Ingredients;reference substance;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Acetylcholine receptor;API;Alkaloids;102518-79-6 |
| Mol File: | 102518-79-6.mol |
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| (-)-Huperzine A Chemical Properties |
| Melting point | 211-216oC |
| alpha | D -147?? (c = 0.36 in CH3OH) (Ayer); D24.5 -150.4?? (c = 0.498 in MeOH) (Liu) |
| Boiling point | 505.0??50.0 ??C(Predicted) |
| density | 1.20??0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8??C |
| solubility | insoluble in H2O; ??12.12 mg/mL in DMSO; ??23.13 mg/mL in EtOH |
| pka | 12.25??0.60(Predicted) |
| form | Solid |
| color | White to Almost white |
| optical activity | [??]/D -153??5??, c = 0.5 in methanol |
| InChI | InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1 |
| InChIKey | ZRJBHWIHUMBLCN-YQEJDHNASA-N |
| SMILES | C12C[C@@]3([H])/C(=CC)/[C@@](N)(C=1C=CC(=O)N2)CC(C)=C3 |
| LogP | 0.833 (est) |
| CAS DataBase Reference | 102518-79-6(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28-36/37/38 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 1544 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | PB9185700 |
| HS Code | 29339900 |
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