Baricitinib CAS 1187594-09-7

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Chemical Name: Baricitinib
CAS No.: 1187594-09-7
Molecular Fomula: C16H17N7O2S
Molecular weight: 371.42
Appearance: White or off white solid
Assay: 99 % min

预计送达： 周六, 8 月 23 – 周三, 8 月 27

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Baricitinib (CAS 1187594-09-7) Comprehensive Guide

Product Specifications & Comparative Analysis
Therapeutic Applications & Mechanism
Clinical Use Cases
Customer Success Stories
Supplier & Inquiry

Product Specifications & Comparative Analysis

Parameter	Baricitinib	Alternative JAK Inhibitors
CAS Number	1187594-09-7	N/A
Molecular Formula	C₁₆H₁₇N₇O₂S	Varies by compound
Molecular Weight	371.42 g/mol	320-450 g/mol
Purity	≥95% (ATKMOL) to ≥99% (MedBio)	Typically ≥98%
Storage	2-8°C, protected from light	Similar requirements

Therapeutic Applications & Mechanism

Primary Indications:

Moderate-to-severe rheumatoid arthritis (RA)
Severe alopecia areata (AA)
COVID-19 cytokine storm management (off-label)

Mechanism: Selective inhibition of JAK1/JAK2 kinases (IC₅₀ 5.7-5.9 nM), modulating IL-6, IFN-γ, and other pro-inflammatory cytokines.

Clinical Use Cases

Case Study 1: Adolescent Alopecia Areata (BRAVE-AA-PEDS Trial)
– 257 patients aged 12-18 with ≥89% scalp hair loss
– 36-week results (4 mg dose):
• 42.4% achieved ≥80% scalp coverage (vs 4.5% placebo)
• 36.5% achieved ≥90% coverage

Case Study 2: Rheumatoid Arthritis (RA-BEACON Trial)
– 527 MTX-IR patients
– 24-week results (4 mg dose):
• ACR20 response: 55% vs 27% placebo
• DAS28-CRP improvement: -1.8 vs -0.6

Customer Success Stories

Pharmaceutical Manufacturer A
– Requirement: 10 kg batch for Phase III trials
– Supplier: Hubei Yuanmeng Bio
– Outcome: 99.2% purity delivered within 4 weeks

Research Institute B
– Requirement: 50 mg analytical reference standard
– Supplier: Shanghai Chaolan Chemical
– Outcome: NMR/HPLC-MS certified material received in 72 hours