Arbutin CAS#497-76-7
Arbutin, a derivative of hydroquinone, is a naturally occurring compound extracted primarily from the bearberry plant (Arctostaphylos uva-ursi). It is renowned in the skincare industry for its skin lightening properties, making it a popular ingredient in cosmetic products designed to reduce hyperpigmentation and even out skin tone.
Chemically, arbutin is ??-glucosiduronic acid of hydroquinone, with the molecular formula C12H12O7. Its mechanism of action involves the inhibition of tyrosinase, a key enzyme in the melanin biosynthesis pathway. By reducing melanin production, arbutin effectively lightens the skin without the risk of irritation often associated with hydroquinone.
Arbutin is valued for its safety profile, as it is considered less irritating and more stable compared to other skin lightening agents. It is also known for its antioxidant properties, which contribute to its skin brightening effects and overall skin health benefits.
In summary, arbutin is a reliable and gentle alternative for skin lightening, offering a natural approach to reducing pigmentation issues while promoting a more radiant and even complexion. Its use in skincare formulations is favored for its efficacy and mildness, making it suitable for various skin types.
| Melting point | 195-198???C |
| Boiling point | 375.31??C (rough estimate) |
| alpha | -64 o (c=3) |
| density | 1.3582 (rough estimate) |
| refractive index | -65.5 ?? (C=4, H2O) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 50?mg/mL hot, clear |
| form | Solid |
| pka | 10.10??0.15(Predicted) |
| color | White |
| optical activity | [??]/D -64.0??2.0??, c = 3 in H2O |
| Water Solubility | 10-15 g/100 mL at 20 oC |
| Sensitive | Hygroscopic |
| Merck | 14,773 |
| BRN | 89673 |
| Stability: | Stable. Hygroscopic – store under dry nitrogen. |
| InChIKey | BJRNKVDFDLYUGJ-RMPHRYRLSA-N |
| LogP | -1.350 |
| CAS DataBase Reference | 497-76-7(CAS DataBase Reference) |
| EPA Substance Registry System | .beta.-D-Glucopyranoside, 4-hydroxyphenyl (497-76-7) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | CE8863000 |
| F | 3-10-23 |
| HS Code | 29389090 |
| Hazardous Substances Data | 497-76-7(Hazardous Substances Data) |
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