LCZ696 Cas 936623-90-4

Lidocaine hydrochloride is an anesthetic as well as an antiarrhythmic drug. Clinically, it is mainly used for infiltration anesthetic, epidural anesthetic, topical anesthesia (consisting of mucosal anesthetic throughout thoracoscopic examination or abdominal surgical treatment) as well as nerve conduction block. It can additionally be used for early ventricular tightenings and also ventricular tachycardia after acute myocardial infarction, and also for ventricular arrhythmias triggered by digitalis poisoning, cardiac surgery as well as cardiac catheterization. But it is usually inadequate for supraventricular arrhythmias.

Urapidil is a sympathetic antihypertensive drug. It acts as ?? 1 ?C adrenoceptor antagonists and 5-HT 1A receptor agonists act. Although the initial report showed that urapidil was also a ?? 2 ?C adrenoceptor agonist, which was not confirmed in later studies, proved that it had no agonist effect in the saphenous vein of dogs and ileum of guinea pigs. With others ?? Unlike 1-adrenoceptor villains, urapidil does not cause response tachycardia, which may be connected to its weak ?? 1-adrenoceptor antagonist activity and its impact on heart vagal drive. Urapidil has actually not been approved by the US Food and drug administration, yet it is offered in Europe.

Urapidil (URA), chemical name is 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl -2,4(1H,3H)-pyrimidinedione, trade name: ebrantil (ebrantil), synonym: excellent matchi, uracil substituted by phenazine.