Polyhexamethyleneguanidine hydrochloride CAS#57028-96-3
Polyhexamethylene guanidine hydrochloride, often abbreviated as PHMG-HCl, is a high molecular weight polymeric biguanide compound known for its potent antimicrobial properties. With a chemical structure that features a long chain of methylene groups bridged by guanidine units, PHMG-HCl is effective against a broad spectrum of microorganisms, including bacteria, viruses, and fungi.
This hydrochloride salt form of PHMG is highly soluble in water and is commonly used in various applications due to its non-irritant and non-toxic nature to human skin and mucous membranes. It is widely recognized for its ability to form a colorless and odorless solution, making it an ideal choice for use in personal care products, medical disinfectants, and water treatment processes.
The versatility of PHMG-HCl lies in its cationic nature, which allows it to bind to negatively charged microbial cell walls, disrupting their integrity and leading to cell death. This mechanism of action contributes to its effectiveness as a preservative and disinfectant. Moreover, its substantivity, or the ability to adhere to surfaces, enhances its long-lasting antimicrobial activity.
In summary, Polyhexamethylene guanidine hydrochloride is a reliable and efficient antimicrobial agent, pivotal in industries where hygiene and cleanliness are paramount, offering a safe and sustainable solution for microbial control.
| Polyhexamethyleneguanidine hydrochloride Chemical Properties |
| Melting point | >222??C (sub.) |
| storage temp. | Refrigerator, Under inert atmosphere |
| solubility | DMSO (Soluble, Heated), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 57028-96-3(CAS DataBase Reference) |
| Polyhexamethyleneguanidine hydrochloride Usage And Synthesis |
| Description | Polyhexamethylene guanidine?(PHMG) is a?guanidine?derivative that is used as a?biocidal?disinfectant, often in the form of its?salt?polyhexamethylene guanidine phosphate?(PHMG-P). |
| Uses | Polyhexamethyleneguanidine Hydrochloride is an Ophthalmic compound containing Phenylephrine. Polyhexamethyleneguanidine Hydrochloride is an antibacterial agent; used in preparation method of multifuctional flame-retardant Polyester fabric. |
| Toxicity | Preliminary findings indicate that PHMG and its derivatives primarily rely on damaging the?cell membrane?by inhibiting the activity of cellular?dehydrogenases.When PHMG is aerosolized and inhaled, it harms the lungs, causing death of the cells lining the?bronchioles?and widespread damage to?alveoli, along with?bronchiolitis obliterans,an often fatal form of non-reversible obstructive?lung?disease in which the bronchiole are compressed and narrowed by?fibrosis?(scar tissue) and/or?inflammation. |
| Chemical Properties | Colorless to pale yellow solution |
| Application | The polymer structure of polyhexamethyleneguanidine hydrochloride (PHGC) reduces its toxicity. However, the sterilization effect is more excellent, and it has been widely used in various fields such as medical and health institutions, family life, food industry and animal husbandry. |
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Polyhexamethylene guanidine hydrochloride, often abbreviated as PHMG-HCl, is a high molecular weight polymeric biguanide compound known for its potent antimicrobial properties. With a chemical structure that features a long chain of methylene groups bridged by guanidine units, PHMG-HCl is effective against a broad spectrum of microorganisms, including bacteria, viruses, and fungi.
This hydrochloride salt form of PHMG is highly soluble in water and is commonly used in various applications due to its non-irritant and non-toxic nature to human skin and mucous membranes. It is widely recognized for its ability to form a colorless and odorless solution, making it an ideal choice for use in personal care products, medical disinfectants, and water treatment processes.
The versatility of PHMG-HCl lies in its cationic nature, which allows it to bind to negatively charged microbial cell walls, disrupting their integrity and leading to cell death. This mechanism of action contributes to its effectiveness as a preservative and disinfectant. Moreover, its substantivity, or the ability to adhere to surfaces, enhances its long-lasting antimicrobial activity.
In summary, Polyhexamethylene guanidine hydrochloride is a reliable and efficient antimicrobial agent, pivotal in industries where hygiene and cleanliness are paramount, offering a safe and sustainable solution for microbial control.
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